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January 12, 2004

The Sinuses: Unplugged
By Kate Jackson

Vol. 16 No. 1 p. 28

Each year, chronic sinusitis afflicts 37 million Americans—more than 15% of the population. It claims more victims than arthritis or hypertension and results in millions of physician office visits and an equal number of dollars spent on medications to relieve symptoms.

Sinusitis—the inflammation of the sinuses—may be acute, generally lasting for fewer than three weeks and often caused by viruses; chronic, spanning a period of three weeks to years and often caused by allergies; or recurrent, characterized by the occurrence of several acute episodes within a year’s time. Although the condition sounds as run-of-the-mill as the common cold (with which it’s often confused), it can result in significant pain, loss of productivity, and social dysfunction for chronic sufferers.

The first line of treatment for chronic sinus disease generally involves treatment of any underlying disorder and administration of a variety of medications or the use of irrigation procedures, or a combination of the two. When these approaches fail or sinusitis is recurrent, some patients may get relief from surgery that improves sinus drainage.

THE SINUSES
At the root of the problem are the four pairs of air-filled, mucosa-lined cavities located within the skull: the frontal sinuses (above the eyes in the area of the brow), the maxillary (beneath the eyes and inside the cheekbones), the ethmoid (between the eyes and behind the bridge of the nose), and the sphenoid (behind the eyes). Each of these sinuses has an opening or duct into the nose that allows air and mucus to flow. The nasal passages and sinuses are lined and joined by a mucous membrane.

Properly functioning sinuses drain through the openings or ducts, releasing their secretions into the nose. Any one or more of the eight sinuses may be affected by sinusitis. When air or secretions are prevented from flowing freely and the sinus becomes swollen and blocked—which may occur as a result of allergies, cold, flu, bacteria, or fungus—pressure may build along the sinus wall, causing pain. The condition becomes chronic when the sinuses remain occluded and their lining swells. A consequence of chronic sinus blockage is the development of polyps in the nose, which in turn often leads to relentless postnasal drip.

SYMPTOMS
The symptoms of sinusitis are highly variable and may include the following:
• pressure or pain over or around the affected sinuses
• nasal discharge
• postnasal drip
• nasal blockage
• cough (often more severe at night)
• fever
• fatigue or malaise
• headache (particularly upon awakening in the morning)
• upper jaw and teeth pain
• tender cheeks over painful teeth and jaw areas
• inflammation of the tear ducts
• swelling of the eyelids and tissues surrounding the eyes
• pain between the eyes
• nasal congestion
• nose sensitive to touch
• loss of sense of smell
• earaches
• neck pain
• ache at the top of the head
• weakness
• sore throat resulting from postnasal drip

Inflammation of the sinuses is caused when ventilation and drainage are occluded. This blockage may occur as a result of a cold virus, bacteria, fungal infections, nasal allergies, polyps, lesions, or an anatomical anomaly such as a deviated septum. Researchers have established a link between allergic rhinitis and chronic sinusitis—sometimes called rhinosinusitis. Some studies have noted that as many as 80% of individuals with chronic sinusitis also suffer from allergic rhinitis. Studies have also demonstrated that as much as 75% of people with asthma experience sinusitis. Also at greater risk are individuals with immune deficiency disease or disorders of mucus flow such as cystic fibrosis. Researchers from the National Institute of Allergy and Infectious Diseases and other organizations are exploring a possible genetic basis for chronic sinusitis.

DIAGNOSIS
In the early stages of an acute attack, the symptoms of sinusitis may mimic those of the common cold or flu. A complete history and review of signs and symptoms will help the healthcare provider distinguish sinusitis from other viral disease so that appropriate treatment may be started promptly. Evaluation by an otolaryngologist is likely to include a medical history and an examination of the interior of the nose with a fiberoptic scope. If a diagnosis cannot be made through history and scoping, imaging studies will be necessary. X-rays may be taken, but they are of limited value and to a large extent have been replaced by limited computed tomography (CT) scans or magnetic resonance imaging scans (MRIs). Coronal CT scans, which may reveal abnormalities of the sinus anatomy, may be indicated for individuals with severe symptoms, complications, or chronic or recurrent sinusitis. Other diagnostic tests may include smell testing, rhinomanometry and nasal cytology, and blood tests.

CONSERVATIVE TREATMENT OF CHRONIC OR RECURRENT SINUSITIS
The first line of attack against sinusitis typically involves medication or irrigation procedures, or a combination of the two. Nasal irrigations using hypertonic saline solutions are intended to thin or wash away the thick mucus that characterizes postnasal drip. The sinuses can be irrigated through the use of nasal douches or a Water Pik device with a nasal irrigation adapter. Medical treatment not only targets the inflammation of the sinuses but also aims to address the underlying cause of inflammation.

Medical treatment might involve antibiotics to conquer infection, antihistamines to combat allergies if they have been identified as a source of sinus difficulty, topical and systemic decongestants, nasal steroid sprays to reduce congestion and swelling, and painkillers. In severe cases, doctors may prescribe oral steroids, such as prednisone, to fight inflammation.

Another conservative tactic stresses nutrition as a weapon against inflammation. Patients are advised to drink large quantities of water, decrease caffeine consumption, limit intake of fatty and sweet foods, and increase their intake of green vegetables, foods high in fatty acids, and tea.

Relief may also be found in home remedies, including over-the-counter saline nasal sprays, vaporizers, and the application of heat to the affected areas. Most patients with sinusitis improve with conservative management. When they fail to respond, if the infection keeps recurring, or when complications occur, surgery may be considered.

SURGERY
When medical treatment fails, surgery, performed by an otolaryngologist, may be the only alternative for treating chronic sinusitis. In the last two decades, advances in imaging techniques (such as CT and MRI) and endoscopic techniques changed the way in which surgeons approached surgical procedures involving the nasal sinuses. Most sinus surgery performed today is minimally invasive, produces little discomfort, has a brief recovery time, and is highly effective, according to studies.

Generally, the goal of surgery is to enlarge the openings that allow the sinuses to drain, but for individuals who have developed polyps as a result of allergies or infections, and for those with structural abnormalities such as a deviated septum, surgeons also want to eliminate or repair the underlying condition.

Functional endoscopic sinus surgery
Although the nasal endoscope has been in use for approximately one-half of a century, it still plays a key role in the surgical treatment of sinus conditions. The most commonly used technique, functional endoscopic sinus surgery (FESS), involves the use of thin, flexible fiberoptic telescopes that improve surgeons’ field of vision, allowing them to visualize areas that were inaccessible before the development of endoscopic technology. This permits FESS, which may target and remove some abnormal tissues in the nose that interfere with drainage and ventilation, to open the pathways to the sinuses to prevent future blockage.

To perform FESS, surgeons advance the endoscope into the nose to visually explore the entrances to the sinuses. Using microsurgical techniques and aided by the telescopes, they can remove diseased tissues directly through the nostrils. Increased drainage and airflow will decrease the inflammation of affected tissues and facilitate a return to a healthy state.

Image-Guided Surgery
Although endoscopic surgery is generally safe and effective, the sinuses are located close to the eyes and the brain and are surrounded by major arteries and neurovascular structures. There’s always a risk that the insertion of the endoscope may result in damage to these delicate areas. The development of sophisticated computer-guided imaging techniques has allowed for techniques that reduce the risk. In the last decade, there’s been a marriage of imaging techniques, such as CT scans, with endoscopic techniques to ensure the accuracy of the endoscope insertion and allow more precision in the placement of microsurgical instruments.

This technology produces a three-dimensional (3-D) triplanal view of an individual’s CT scan and delivers real-time mapping information that relies upon infrared signals, which allow surgeons to more accurately pinpoint problem areas and advance instruments through dense or otherwise difficult-to-navigate sinus passages, particularly in patients with severe disease, those who previously had anatomy-altering sinus surgery, and those with structural abnormalities. In preparation for the procedure, patients are outfitted with a framed plastic helmet (inside of which are small magnets) and given a CT scan. The images from the scan are saved in the computer, where a 3-D model of the patients’ sinuses is developed.

This technology, which is based upon military tracking and guidance principles, has vastly improved surgeons’ ability to eradicate sinus disease and bring comfort and relief to patients who have not responded to more conservative approaches. During surgery, the patients wear the same helmet that is now attached to a probe that generates a magnetic field. As the probe moves through the magnetic field, the 3-D CT scan images change to match each new area probed. Small arrows appear on the computer display to indicate the location of the instruments so that the surgeons know precisely how they’re advancing through the complex terrain of the sinuses. Recovery is swift—from three to five days—and the surgery results in no external swelling or bruising.

Caldwell-Luc operation
Another option is the Caldwell-Luc operation. In this procedure, surgeons address chronic sinusitis or a malignancy in the sinus by accessing the maxillary sinus through the patient’s upper jaw above one of the second molar teeth and opening the sinus into the nose to facilitate drainage.

Recovery
Patients are typically scheduled for follow-up visits one week and two weeks following surgery. At these visits, the nose is cleaned and any implants that may have been inserted are removed. Although there is little postoperative discomfort, patients are advised to avoid physical strain for several days and physical exercise for two or three weeks. Complications, which are rare, include fever, pain, infection, bleeding, and recurrent sinusitis. Depending on the location of the sinuses affected, smell or vision disorders may result, or central nervous system complications may arise. When caught earlier, complications are generally treated easily and successfully.

Sinusitis leads to considerable suffering and reduced quality of life as it places a drain on the healthcare economy. Because it can affect all ages and tends to be recurrent, it interferes with productivity at work and achievement at school. However, early and accurate diagnosis of symptoms and prompt and appropriate treatment by a specialist can relieve sinus misery and greatly improve the quality of life for millions of Americans.

— Kate Jackson is a staff writer at For the Record.

For more information about sinusitis, visit:

American Academy of Allergy, Asthma and Immunology
www.aaaai.org

American Academy of Otolaryngology-Head and Neck Surgery, Inc.
www.entnet.org

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